Radiographic patterns of recurrence and pathologic correlation in malignant gliomas treated with bevacizumab. Academic Article uri icon

Overview

abstract

  • UNLABELLED: Interpretation of MRI abnormalities in patients with malignant gliomas (MG) treated with bevacizumab is challenging. Recent reports describe quantitative analyses of diffusion-weighted imaging abnormalities not available in standard clinical settings, to differentiate tumor recurrence from treatment necrosis. We retrospectively reviewed bevacizumab treated MG patients who underwent surgery or autopsy to correlate radiographic recurrence patterns with pathologic findings. 32 patients with MG (26 glioblastoma, three anaplastic astrocytoma and three anaplastic oligodendroglioma) were identified. Recurrence patterns: local enhancing (n = 23), distant enhancing (n = 1), nonenhancing (n = 7) and leptomeningeal (n = 1). HISTOLOGY: tumor (n = 25), mixed tumor/necrosis (n = 5) and all necrosis (n = 2). On diffusion-weighted imaging, 5/32 had restricted diffusion (three mixed and two necrosis). Irrespective of radiographic recurrence pattern, tumor was found in 94% of cases. Restricted diffusion correlated with necrosis.

publication date

  • February 1, 2018

Research

keywords

  • Antineoplastic Agents, Immunological
  • Bevacizumab
  • Brain
  • Brain Neoplasms
  • Glioma
  • Neoplasm Recurrence, Local

Identity

PubMed Central ID

  • PMC6001559

Scopus Document Identifier

  • 85059797836

Digital Object Identifier (DOI)

  • 10.2217/cns-2017-0025

PubMed ID

  • 29388793

Additional Document Info

volume

  • 7

issue

  • 1