Inter-operator variability in compartmental kinetic analysis of 18F-fluoromisonidazole dynamic PET. Academic Article uri icon

Overview

abstract

  • PURPOSE: To assess the inter-operator variability in compartment analysis (CA) of dynamic-FMISO (dyn-FMISO) PET. METHODS: Study-I: Five investigators conducted CA for 23 NSCLC dyn-FMISO tumor time-activity-curves. Study-II: Four operators performed CA for four NSCLC dyn-FMISO datasets. Repeatability of Kinetic-Rate-Constants (KRCs) was assessed. RESULTS: Study-I: Strong correlation (ICC > 0.9) and interchangeable results among operators existed for all KRCs. Study-II: Up to 103% variability in tumor segmentation, and weaker ICC in KRCs (ICC-VB = 0.53; ICC-K1 = 0.91; ICC-K1/k2 = 0.25; ICC-k3 = 0.32; ICC-Ki = 0.54) existed. All KRCs were repeatable among the different operators. CONCLUSIONS: Inter-operator variability in CA of dyn-FMISO was shown to be within statistical errors.

publication date

  • January 12, 2018

Research

keywords

  • Carcinoma, Non-Small-Cell Lung
  • Lung Neoplasms
  • Misonidazole
  • Positron-Emission Tomography
  • Radiopharmaceuticals

Identity

PubMed Central ID

  • PMC6059771

Scopus Document Identifier

  • 85041458238

Digital Object Identifier (DOI)

  • 10.1016/j.clinimag.2017.12.015

PubMed ID

  • 29414505

Additional Document Info

volume

  • 49