Treatment of antiphospholipid syndrome beyond anticoagulation. Review uri icon

Overview

abstract

  • Antiphospholipid syndrome (APS) is a systemic autoimmune disorder marked by thrombosis and/or pregnancy morbidity in the presence of antiphospholipid antibodies (aPL). At the present time, treatment is primarily focused on anticoagulation. However, there is increasing awareness of the mechanisms involved in APS pathogenesis, which has led to the trial of novel therapies targeting those mechanisms. Following a brief review of the etiopathogenesis of and current management strategies in APS, this paper focuses on the evidence for these potential, targeted APS treatments, e.g., hydroxychloroquine, statins, rituximab, belimumab, eculizumab, defibrotide, sirolimus, and peptide therapy.

publication date

  • March 3, 2018

Research

keywords

  • Antiphospholipid Syndrome
  • Immunosuppressive Agents

Identity

Scopus Document Identifier

  • 85046106427

Digital Object Identifier (DOI)

  • 10.1016/j.clim.2018.03.001

PubMed ID

  • 29510235

Additional Document Info

volume

  • 206