Interferon induction by adenovirus type 12: stimulatory function of early region 1A. Academic Article uri icon

Overview

abstract

  • Adenoviruses are generally weak interferon inducers, triggering chicken embryo fibroblast cells by a UV-resistant viral component, probably the capsid or capsid elements, to produce 50 to 100 IU of interferon per ml. Adenovirus types 12, 18, and 31, however, can induce by a UV-sensitive mechanism 10 to 20 times more interferon than other types do. By using mutant and recombinant adenoviruses, we demonstrated that early region 1A was responsible for the enhanced interferon production of chicken cells infected with adenovirus type 12.

publication date

  • July 1, 1987

Research

keywords

  • Adenoviridae
  • Interferon Type I
  • Oncogene Proteins, Viral

Identity

PubMed Central ID

  • PMC283702

Scopus Document Identifier

  • 0023194214

Digital Object Identifier (DOI)

  • 10.1128/JVI.61.7.2326-2330.1987

PubMed ID

  • 2953908

Additional Document Info

volume

  • 61

issue

  • 7