Enhanced Replication of Highly Pathogenic Influenza A(H7N9) Virus in Humans. Academic Article uri icon

Overview

abstract

  • To clarify the threat posed by emergence of highly pathogenic influenza A(H7N9) virus infection among humans, we characterized the viral polymerase complex. Polymerase basic 2-482R, polymerase basic 2-588V, and polymerase acidic-497R individually or additively enhanced virus polymerase activity, indicating that multiple replication-enhancing mutations in 1 isolate may contribute to virulence.

publication date

  • April 1, 2018

Research

keywords

  • Influenza A Virus, H7N9 Subtype
  • Influenza, Human
  • Virus Replication

Identity

PubMed Central ID

  • PMC5875272

Scopus Document Identifier

  • 85044180246

Digital Object Identifier (DOI)

  • 10.1038/nature16474

PubMed ID

  • 29553313

Additional Document Info

volume

  • 24

issue

  • 4