Ambient PM2.5 air pollution exposure and hepatocellular carcinoma incidence in the United States. Academic Article uri icon

Overview

abstract

  • PURPOSE: To conduct the first epidemiologic study prospectively examining the association between particulate matter air pollution < 2.5 µm in diameter (PM2.5) exposure and hepatocellular carcinoma (HCC) risk in the U.S. METHODS: Surveillance, Epidemiology, and End Results (SEER) provided information on HCC cases diagnosed between 2000 and 2014 from 16 population-based cancer registries across the U.S. Ambient PM2.5 exposure was estimated by linking the SEER county with a spatial PM2.5 model using a geographic information system. Poisson regression with robust variance estimation was used to calculate incidence rate ratios and 95% confidence intervals (CIs) for the association between ambient PM2.5 exposure per 10 µg/m3 increase and HCC risk adjusting for individual-level age at diagnosis, sex, race, year of diagnosis, SEER registry, and county-level information on health conditions, lifestyle, demographic, socioeconomic, and environmental factors. RESULTS: Higher levels of ambient PM2.5 exposure were associated with a statistically significant increased risk for HCC (n = 56,245 cases; adjusted IRR per 10 µg/m3 increase = 1.26, 95% CI 1.08, 1.47; p < 0.01). CONCLUSIONS: If confirmed in studies with individual-level PM2.5 exposure and risk factor information, these results suggest that ambient PM2.5 exposure may be a risk factor for HCC in the U.S.

publication date

  • April 25, 2018

Research

keywords

  • Air Pollution
  • Carcinoma, Hepatocellular
  • Liver Neoplasms
  • Particulate Matter

Identity

PubMed Central ID

  • PMC5940508

Scopus Document Identifier

  • 85046014878

Digital Object Identifier (DOI)

  • 10.1097/01.EDE.0000041910.49046.9B

PubMed ID

  • 29696510

Additional Document Info

volume

  • 29

issue

  • 6