Functional Imaging Methods for Assessment of Minimal Residual Disease in Multiple Myeloma: Current Status and Novel ImmunoPET Based Methods. Review uri icon

Overview

abstract

  • Imaging plays a key role in assessment of myeloma. Osteolytic bone lesions are optimally assessed using structural imaging, however the structural changes lag the functional changes in the disease. Functional imaging with fluoro deoxy glucose (FDG) positron emission tomography (PET) computerized tomography (CT) is useful in assessment of high-risk myeloma. FDG PET provides prognostic information and is helpful in monitoring response to therapy. However, it is nonspecific and may not be optimal in assessing treatment response to immunotherapeutic agents. Imaging with targeted agents may allow for better assessment of changes from therapy, that is based on the specific targeted mechanism. ImmunoPET imaging is a novel method to assess targeting of specific antigen by therapeutic antibodies. This review summarizes the role of functional imaging and development of novel immunoPET agents for assessment of treatment response and residual disease.

publication date

  • March 5, 2018

Research

keywords

  • Multiple Myeloma
  • Neoplasm, Residual
  • Positron-Emission Tomography

Identity

PubMed Central ID

  • PMC7549432

Scopus Document Identifier

  • 85045562475

Digital Object Identifier (DOI)

  • 10.1038/leu.2013.292

PubMed ID

  • 29759149

Additional Document Info

volume

  • 55

issue

  • 1