TGF-β Sustains Tumor Progression through Biochemical and Mechanical Signal Transduction. Review uri icon

Overview

abstract

  • Transforming growth factor β (TGF-β) signaling transduces immunosuppressive biochemical and mechanical signals in the tumor microenvironment. In addition to canonical SMAD transcription factor signaling, TGF-β can promote tumor growth and survival by inhibiting proinflammatory signaling and extracellular matrix (ECM) remodeling. In this article, we review how TGF-β activated kinase 1 (TAK1) activation lies at the intersection of proinflammatory signaling by immune receptors and anti-inflammatory signaling by TGF-β receptors. Additionally, we discuss the role of TGF-β in the mechanobiology of cancer. Understanding how TGF-β dampens proinflammatory responses and induces pro-survival mechanical signals throughout cancer development is critical for designing therapeutics that inhibit tumor progression while bolstering the immune response.

publication date

  • June 14, 2018

Identity

PubMed Central ID

  • PMC6025279

Scopus Document Identifier

  • 84939572294

Digital Object Identifier (DOI)

  • 10.1016/j.tibtech.2015.01.004

PubMed ID

  • 29903994

Additional Document Info

volume

  • 10

issue

  • 6