Short Communication: Protective Efficacy of Broadly Neutralizing Antibody PGDM1400 Against HIV-1 Challenge in Humanized Mice. Academic Article uri icon

Overview

abstract

  • Broadly neutralizing antibodies (bNAbs) such as PGDM1400 show promise as prophylactic and therapeutic agents against HIV-1. Human immune system mice were passively immunized with different doses of PGDM1400 and challenged 24 h later with a high dose of HIV-1JRCSF. We found that PGDM1400 provided protection against HIV-1 challenge in a concentration dependent manner and that the protective concentration in blood was ∼75-fold higher than the in vitro 50% inhibitory concentration. The results demonstrate that PGDM1400 might be a promising component of strategies to prevent HIV-1 infection and provide support for the pursuit of vaccines that induce PGDM1400-like bNAbs.

publication date

  • August 22, 2018

Research

keywords

  • Antibodies, Neutralizing
  • HIV Antibodies
  • HIV Infections
  • HIV-1

Identity

Scopus Document Identifier

  • 85053671882

Digital Object Identifier (DOI)

  • 10.1089/AID.2018.0114

PubMed ID

  • 30003812

Additional Document Info

volume

  • 34

issue

  • 9