Efficacy of combination therapy with efinaconazole 10% solution and 1064 nm Nd:YAG laser for treatment of toenail onychomycosis. Academic Article uri icon

Overview

abstract

  • BACKGROUND: Onychomycosis is a common but difficult to treat nail disorder. Treatment strategies thus far have included oral and topical antifungals, surgical treatment and recently lasers have emerged as a therapeutic modality. OBJECTIVE: The objective of this study was to assess whether efinaconazole together with laser would result in greater clinical and mycologic cure and lower rate of relapse compared to efinaconazole alone. METHODS: Thirty subjects were randomized to either self-apply efinaconazole 10% once daily for 48 weeks, or follow the same treatment plan but also receive six treatments with a 1064 nm Nd: YAG laser every 4 weeks. The primary endpoint was to assess the proportion of subjects who achieved complete cure at week 52. RESULTS: The combination therapy group showed significantly quicker mycological cure at the 48- and 52-week follow-up. CONCLUSION: Both efinaconazole and combination with laser were efficacious treatment, but the combination therapy leads to quicker resolution with fewer rate of relapse.

publication date

  • July 27, 2018

Research

keywords

  • Antifungal Agents
  • Foot Dermatoses
  • Laser Therapy
  • Lasers, Solid-State
  • Onychomycosis
  • Triazoles

Identity

Scopus Document Identifier

  • 85050979936

Digital Object Identifier (DOI)

  • 10.1080/14764172.2018.1502451

PubMed ID

  • 30052090

Additional Document Info

volume

  • 21

issue

  • 3