Cystamine and cysteamine as inhibitors of transglutaminase activity in vivo. Review uri icon

Overview

abstract

  • Cystamine is commonly used as a transglutaminase inhibitor. This disulphide undergoes reduction in vivo to the aminothiol compound, cysteamine. Thus, the mechanism by which cystamine inhibits transglutaminase activity in vivo could be due to either cystamine or cysteamine, which depends on the local redox environment. Cystamine inactivates transglutaminases by promoting the oxidation of two vicinal cysteine residues on the enzyme to an allosteric disulphide, whereas cysteamine acts as a competitive inhibitor for transamidation reactions catalyzed by this enzyme. The latter mechanism is likely to result in the formation of a unique biomarker, N-(γ-glutamyl)cysteamine that could serve to indicate how cyst(e)amine acts to inhibit transglutaminases inside cells and the body.

publication date

  • September 5, 2018

Research

keywords

  • Cystamine
  • Cysteamine
  • Enzyme Inhibitors
  • Transglutaminases

Identity

PubMed Central ID

  • PMC6123069

Scopus Document Identifier

  • 85052974983

Digital Object Identifier (DOI)

  • 10.1080/03007995.2017.1354288

PubMed ID

  • 30054429

Additional Document Info

volume

  • 38

issue

  • 5