Genesis of polarity in renal tubular cells. Review uri icon

Overview

abstract

  • Using enveloped RNA viruses as probes to study the biogenesis of surface polarity in epithelial cell lines, evidence has been obtained that, as shown for secretion in exocrine cells, the delivery of plasma membrane proteins to the cell surface is polarized. Divergence between the pathways of apical and basolateral plasma membrane proteins occurs at the level of the distal Golgi apparatus. Presumably, carrier vesicles with affinity for specific receptors in the apical or in the basolateral regions of the plasmalemma participate in the transport between the Golgi apparatus and the cell surface. Agents which disrupt actin filaments and microtubules do not alter significantly this process of vectorial exocytosis.

publication date

  • January 1, 1986

Research

keywords

  • Kidney Tubules
  • Membrane Glycoproteins
  • Membrane Proteins

Identity

Scopus Document Identifier

  • 0022653009

PubMed ID

  • 3007959

Additional Document Info

volume

  • 12

issue

  • 1