Partial N-terminal amino acid sequences of three nonstructural proteins of two flaviviruses. Academic Article uri icon

Overview

abstract

  • Partial N-terminal amino acid sequences for the three largest nonstructural proteins of two flaviviruses, yellow fever virus and St. Louis encephalitis virus, have been obtained. The determined sequences of these proteins exhibit significant amino acid sequence homology, and allow the positioning of these three nonstructural proteins in the polyprotein sequence deduced from the nucleotide sequence of yellow fever virus (C. M. Rice, E. M. Lenches, S. R. Eddy, S. J. Shin, R. L. Sheets, and J. H. Strauss, 1985, Science 229, 726-733.) The deduced start points support the hypothesis that the N terminus of nonstructural glycoprotein NS1 results from cleavage by signalase, whereas the N termini of NS3 and NS5 result from cleavages following double basic residues that are flanked by amino acids with short side chains.

authors

  • Rice, Charles M.
  • Aebersold, Ruedi
  • Teplow, D B
  • Pata, Janice
  • Bell, J R
  • Vorndam, A V
  • Trent, D W
  • Brandriss, M W
  • Schlesinger, J J
  • Strauss, J H

publication date

  • May 1, 1986

Research

keywords

  • Encephalitis Virus, St. Louis
  • Flavivirus
  • Viral Proteins
  • Yellow fever virus

Identity

Scopus Document Identifier

  • 0022600842

Digital Object Identifier (DOI)

  • 10.1016/0042-6822(86)90098-x

PubMed ID

  • 3008425

Additional Document Info

volume

  • 151

issue

  • 1