Gestational diabetes reverses the circadian variation of plasma insulin response to intravenous glucose. Academic Article uri icon

Overview

abstract

  • Both healthy third-trimester pregnant women and a group of women with gestational diabetes failed to show a difference in glucose clearance rates when given an intravenous glucose bolus at 8 AM compared with 4 PM. The plasma insulin response in the healthy pregnant women was greater at 8 AM. In the diabetic group, the peak insulin response was greater at 4 PM, but it was more prolonged after the 8 AM tests. These alterations in plasma insulin response were especially striking in the subgroup of obese women with gestational diabetes, who demonstrated metabolic differences compared with their nonobese counterparts.

publication date

  • September 1, 1988

Research

keywords

  • Circadian Rhythm
  • Glucose Tolerance Test
  • Insulin
  • Pregnancy in Diabetics

Identity

Scopus Document Identifier

  • 0023695274

Digital Object Identifier (DOI)

  • 10.1016/s0002-9378(88)80018-8

PubMed ID

  • 3048098

Additional Document Info

volume

  • 159

issue

  • 3