Mature dendritic cells correlate with favorable immune infiltrate and improved prognosis in ovarian carcinoma patients. Academic Article uri icon

Overview

abstract

  • A high density of tumor-infiltrating CD8+ T cells and CD20+ B cells correlates with prolonged survival in patients with a wide variety of human cancers, including high-grade serous ovarian carcinoma (HGSC). However, the potential impact of mature dendritic cells (DCs) in shaping the immune contexture of HGSC, their role in the establishment of T cell-dependent antitumor immunity, and their potential prognostic value for HGSC patients remain unclear. We harnessed immunohistochemical tests and biomolecular analyses to demonstrate that a high density of tumor-infiltrating DC-LAMP+ DCs is robustly associated with an immune contexture characterized by TH1 polarization and cytotoxic activity. We showed that both mature DCs and CD20+ B cells play a critical role in the generation of a clinically-favorable cytotoxic immune response in HGSC microenvironment. In line with this notion, robust tumor infiltration by both DC-LAMP+ DCs and CD20+ B cells was associated with most favorable overall survival in two independent cohorts of chemotherapy-naïve HGSC patients. Our findings suggest that the presence of mature, DC-LAMP+ DCs in the tumor microenvironment may represent a novel, powerful prognostic biomarker for HGSC patients that reflects the activation of clinically-relevant anticancer immunity.

publication date

  • December 4, 2018

Research

keywords

  • Carcinoma
  • Dendritic Cells
  • Ovarian Neoplasms
  • Tumor Microenvironment

Identity

PubMed Central ID

  • PMC6288908

Scopus Document Identifier

  • 85058319459

Digital Object Identifier (DOI)

  • 10.1146/annurev-immunol-100311-102839

PubMed ID

  • 30526667

Additional Document Info

volume

  • 6

issue

  • 1