Trastuzumab gold-conjugates: synthetic approach and in vitro evaluation of anticancer activities in breast cancer cell lines. Academic Article uri icon

Overview

abstract

  • We describe the preparation of gold(i)-compounds that are amenable to efficient bioconjugation with monoclonal antibodies via activated ester or maleimide linkers. New Trastuzumab-gold conjugates were synthesized and fully characterized. These bioconjugates are significantly more cytotoxic (sub-micromolar range) to HER2-positive breast cancer cells than the gold complexes and Trastuzumab.

publication date

  • January 29, 2019

Research

keywords

  • Antineoplastic Agents, Immunological
  • Gold
  • Trastuzumab

Identity

PubMed Central ID

  • PMC6691192

Scopus Document Identifier

  • 85060617422

Digital Object Identifier (DOI)

  • 10.1039/C8CS00570B

PubMed ID

  • 30632546

Additional Document Info

volume

  • 55

issue

  • 10