Dynamic Contrast-Enhanced MRI Reveals Unique Blood-Brain Barrier Permeability Characteristics in the Hippocampus in the Normal Brain. Academic Article uri icon

Overview

abstract

  • We report a prospective dynamic contrast-enhanced MR imaging analysis of region-specific blood-brain barrier permeability in 5 healthy subjects. By means of standardized postprocessing and ROI sampling methods, the hippocampi revealed significantly elevated area under the dynamic contrast-enhanced curve and significantly increased blood-brain barrier permeability metrics (volume transfer constant and volume in the extravascular extracellular space) from model-based quantitation. These findings suggest unique blood-brain barrier permeability characteristics in the hippocampus, which are concordant with previous animal studies, potentially laying the groundwork for future studies assessing patient populations in which hippocampal pathology plays a role.

publication date

  • February 7, 2019

Research

keywords

  • Blood-Brain Barrier
  • Hippocampus
  • Magnetic Resonance Imaging
  • Neuroimaging

Identity

PubMed Central ID

  • PMC7028673

Scopus Document Identifier

  • 85062948458

Digital Object Identifier (DOI)

  • 10.1002/art.38852

PubMed ID

  • 30733256

Additional Document Info

volume

  • 40

issue

  • 3