Peripheral and systemic antigens elicit an expandable pool of resident memory CD8+ T cells in the bone marrow. Academic Article uri icon

Overview

abstract

  • BM has been put forward as a major reservoir for memory CD8+ T cells. In order to fulfill that function, BM should "store" memory CD8+ T cells, which in biological terms would require these "stored" memory cells to be in disequilibrium with the circulatory pool. This issue is a matter of ongoing debate. Here, we unequivocally demonstrate that murine and human BM harbors a population of tissue-resident memory CD8+ T (TRM ) cells. These cells develop against various pathogens, independently of BM infection or local antigen recognition. BM CD8+ TRM cells share a transcriptional program with resident lymphoid cells in other tissues; they are polyfunctional cytokine producers and dependent on IL-15, Blimp-1, and Hobit. CD8+ TRM cells reside in the BM parenchyma, but are in close contact with the circulation. Moreover, this pool of resident T cells is not size-restricted and expands upon peripheral antigenic re-challenge. This works extends the role of the BM in the maintenance of CD8+ T cell memory to include the preservation of an expandable reservoir of functional, non-recirculating memory CD8+ T cells, which develop in response to a large variety of peripheral antigens.

publication date

  • April 2, 2019

Research

keywords

  • Bone Marrow Cells
  • CD8-Positive T-Lymphocytes
  • Immunologic Memory
  • T-Lymphocyte Subsets

Identity

PubMed Central ID

  • PMC6594027

Scopus Document Identifier

  • 85063768380

Digital Object Identifier (DOI)

  • 10.1002/minf.201600132

PubMed ID

  • 30891737

Additional Document Info

volume

  • 49

issue

  • 6