Squamous Cell Carcinoma In Situ With Occult Invasion: A Tertiary Care Institutional Experience. Academic Article uri icon

Overview

abstract

  • BACKGROUND: The rate of occult invasive disease within biopsy-proven squamous cell carcinoma in situ (SCCIS) is not well defined. OBJECTIVE: To examine the rate of occult invasion in SCCIS. METHODS: An institutional-wide pathology database was retrospectively searched for "squamous cell carcinoma in situ" over a 6-year period, and the treatment modality and final pathology results were analyzed for evidence of invasion. In addition, consecutive tumor blocks from Mohs micrographic surgery (MMS) cases of SCCIS were prospectively analyzed for invasion. RESULTS: The rate of occult invasion for biopsy-proven SCCIS treated with excision was 4.0% (N = 49) and for the MMS margins was 3.5% (N = 310). For the prospective MMS tumor block analysis, the rate of occult invasion was 10.1% (N = 69). No clinical factors (age, sex, location, or size) correlated with increased risk of invasion. All invasive SCCs detected were superficial and well differentiated. CONCLUSION: The rate of occult invasion for biopsy-proven SCCIS ranged from 3.5% to 10.1%. The detected rate of invasion varies based on the method of excision and pathology processing of specimens. The rate of invasion should be considered when managing SSCIS.

publication date

  • November 1, 2019

Research

keywords

  • Carcinoma in Situ
  • Carcinoma, Squamous Cell
  • Mohs Surgery
  • Skin Neoplasms

Identity

PubMed Central ID

  • PMC8862785

Scopus Document Identifier

  • 85074119050

Digital Object Identifier (DOI)

  • 10.1097/DSS.0000000000001028

PubMed ID

  • 30893175

Additional Document Info

volume

  • 45

issue

  • 11