Whole Blood Serotonin Levels and Platelet 5-HT2A Binding in Autism Spectrum Disorder. Academic Article uri icon

Overview

abstract

  • Elevated whole blood serotonin (WB5-HT) is a well-replicated biomarker in autism spectrum disorder (ASD). Decreased platelet serotonin receptor 5-HT2A binding has been reported in ASD. WB5-HT levels and platelet 5-HT2A specific binding were obtained from 110 individuals with ASD and 18 controls. Individuals with ASD had significantly higher WB5-HT levels than controls. There was no difference in the platelet 5-HT2A specific binding between groups. Multiple regression analyses revealed that platelet 5-HT2A binding significantly predicted WB5-HT in the control sample but not in the ASD sample. These results indicate that the relationship between WB5-HT and platelet 5-HT2A binding differs depending on ASD diagnosis, suggesting differences in platelet 5-HT system regulation in ASD.

publication date

  • June 1, 2019

Research

keywords

  • Autism Spectrum Disorder
  • Blood Platelets
  • Receptor, Serotonin, 5-HT2A
  • Serotonin

Identity

PubMed Central ID

  • PMC6549243

Scopus Document Identifier

  • 85064089681

Digital Object Identifier (DOI)

  • 10.1002/aur.1317

PubMed ID

  • 30927179

Additional Document Info

volume

  • 49

issue

  • 6