Young donors with severe acute kidney injury offer an opportunity to expand the donor pool. Academic Article uri icon

Overview

abstract

  • BACKGROUND: This study assessed our experience transplanting kidneys from young donors with severe acute kidney injury. METHODS: We performed a single center retrospective analysis of 315 kidney transplants between 1/1/2014-12/31/2016. Donor kidneys were classified according to the Acute Kidney Injury Network (AKIN) criteria. A case-matched cohort was created using recipient age, history of diabetes, donor specific antibody, donor age and donor after cardiac death. Primary endpoints were graft function measured by eGFR at 90 days and at 1-year. RESULTS: Stage 3 AKIN recipients had significantly greater eGFR at one year (63.9 ml/min v. 51.2 ml/min, p < 0.001) compared to those with Stage 0 AKIN. This difference was abrogated when compared to a case matched cohort (eGFR at 90 days or 1 year; p > 0.05). Donor and recipient characteristics on eGFR at 1 year were analyzed using linear and logistic regression. Only donor age had a significant impact on recipient eGFR. CONCLUSIONS: Donor kidneys with severe acute injury can achieve optimal 1-year outcomes. Donor age is the most significant predictor of eGFR >45 ml/min after transplant.

publication date

  • April 12, 2019

Research

keywords

  • Acute Kidney Injury
  • Kidney Transplantation
  • Tissue Donors

Identity

Scopus Document Identifier

  • 85064182468

Digital Object Identifier (DOI)

  • 10.1016/j.amjsurg.2019.04.005

PubMed ID

  • 31003717

Additional Document Info

volume

  • 218

issue

  • 1