When fat goes down, prostate cancer is on the ropes. Academic Article uri icon

Overview

abstract

  • Reprogrammed lipid metabolism and persistent androgen receptor signaling commonly mark aggressive prostate cancer. We describe that targeting de-novo lipogenesis deprives prostate cancer cells of substrates and fuel, while inhibiting androgen receptor signaling. Our study uncovers the interplay between lipogenesis and androgen receptor and proposes novel combinatorial therapeutic approaches.

publication date

  • April 16, 2019

Identity

PubMed Central ID

  • PMC6512936

Scopus Document Identifier

  • 85040653917

Digital Object Identifier (DOI)

  • 10.1038/s41588-017-0027-2

PubMed ID

  • 31131311

Additional Document Info

volume

  • 6

issue

  • 3