Somatic and germline sequencing in genitourinary oncology: genetics for the clinician. Review uri icon

Overview

abstract

  • PURPOSE OF REVIEW: Next-generation sequencing is becoming more accessible. This review focuses on the clinical application of somatic and germline sequencing to genitourinary oncology. RECENT FINDINGS: Germline variants have been increasingly recognized as contributing to the development of genitourinary malignancies, particularly in patients with advanced disease. A variety of commercial and institutional technologies are in use to detect variants, with newer tools focused on integrating these results into the clinical workflow. SUMMARY: DNA sequencing is becoming a valuable tool in caring for patients with genitourinary malignancies. Performing both somatic and germline sequencing will likely become standard practice. Interpretation and clinical application of these results can be challenging and often requires multidisciplinary expertise.

publication date

  • July 1, 2019

Research

keywords

  • Sequence Analysis, DNA
  • Urogenital Neoplasms

Identity

PubMed Central ID

  • PMC9467627

Scopus Document Identifier

  • 85067199830

Digital Object Identifier (DOI)

  • 10.1097/MOU.0000000000000643

PubMed ID

  • 31158105

Additional Document Info

volume

  • 29

issue

  • 4