Autophagy-Independent Functions of the Autophagy Machinery. Review uri icon

Overview

abstract

  • Macroautophagy (herein referred to as autophagy) is an evolutionary ancient mechanism that culminates with the lysosomal degradation of superfluous or potentially dangerous cytosolic entities. Over the past 2 decades, the molecular mechanisms underlying several variants of autophagy have been characterized in detail. Accumulating evidence suggests that most, if not all, components of the molecular machinery for autophagy also mediate autophagy-independent functions. Here, we discuss emerging data on the non-autophagic functions of autophagy-relevant proteins.

publication date

  • June 13, 2019

Research

keywords

  • Autophagy
  • Autophagy-Related Proteins
  • Lysosomes

Identity

PubMed Central ID

  • PMC7173070

Scopus Document Identifier

  • 85066813673

Digital Object Identifier (DOI)

  • 10.7554/eLife.03706

PubMed ID

  • 31199916

Additional Document Info

volume

  • 177

issue

  • 7