Why the Gold Standard Approach by Mammography Demands Extension by Multiomics? Application of Liquid Biopsy miRNA Profiles to Breast Cancer Disease Management. Review uri icon

Overview

abstract

  • In the global context, the epidemic of breast cancer (BC) is evident for the early 21st century. Evidence shows that national mammography screening programs have sufficiently reduced BC related mortality. Therefore, the great utility of the mammography-based screening is not an issue. However, both false positive and false negative BC diagnosis, excessive biopsies, and irradiation linked to mammography application, as well as sub-optimal mammography-based screening, such as in the case of high-dense breast tissue in young females, altogether increase awareness among the experts regarding the limitations of mammography-based screening. Severe concerns regarding the mammography as the "golden standard" approach demanding complementary tools to cover the evident deficits led the authors to present innovative strategies, which would sufficiently improve the quality of the BC management and services to the patient. Contextually, this article provides insights into mammography deficits and current clinical data demonstrating the great potential of non-invasive diagnostic tools utilizing circulating miRNA profiles as an adjunct to conventional mammography for the population screening and personalization of BC management.

publication date

  • June 13, 2019

Research

keywords

  • Biomarkers, Tumor
  • Breast Neoplasms
  • Genomics
  • Mammography
  • MicroRNAs

Identity

PubMed Central ID

  • PMC6627787

Scopus Document Identifier

  • 85068141313

Digital Object Identifier (DOI)

  • 10.1186/s13167-016-0072-4

PubMed ID

  • 31200461

Additional Document Info

volume

  • 20

issue

  • 12