Metabolic signatures of cancer cells and stem cells. Review uri icon

Overview

abstract

  • In contrast to terminally differentiated cells, cancer cells and stem cells retain the ability to re-enter the cell cycle and proliferate. In order to proliferate, cells must increase the uptake and catabolism of nutrients to support anabolic cell growth. Intermediates of central metabolic pathways have emerged as key players that can influence cell differentiation 'decisions', processes relevant for both oncogenesis and normal development. Consequently, how cells rewire metabolic pathways to support proliferation may have profound consequences for cellular identity. Here, we discuss the metabolic programs that support proliferation and explore how metabolic states are intimately entwined with the cell fate decisions that characterize stem cells and cancer cells. By comparing the metabolism of pluripotent stem cells and cancer cells, we hope to illuminate common metabolic strategies as well as distinct metabolic features that may represent specialized adaptations to unique cellular demands.

publication date

  • February 11, 2019

Research

keywords

  • Metabolic Networks and Pathways
  • Neoplasms
  • Stem Cells

Identity

PubMed Central ID

  • PMC6594714

Scopus Document Identifier

  • 85065884574

Digital Object Identifier (DOI)

  • 10.1016/j.celrep.2017.02.016

PubMed ID

  • 31245788

Additional Document Info

volume

  • 1

issue

  • 2