Activity of Imipenem-Relebactam and Comparator Agents against Genetically Characterized Isolates of Carbapenem-Resistant Enterobacteriaceae. Academic Article uri icon

Overview

abstract

  • Carbapenem-resistant Enterobacteriaceae (CRE) strains are an urgent public health threat. We evaluated the in vitro activities of 19 antimicrobial agents, including imipenem-relebactam, against (i) 106 CRE bloodstream isolates that primarily expressed Klebsiella pneumoniae carbapenemase (KPC) and (ii) 20 OXA-48-like-expressing CRE isolates. Ninety-five percent of CRE bloodstream isolates were susceptible to imipenem-relebactam. In contrast to their comparable activities against KPC-producing CRE strains, ceftazidime-avibactam was more active in vitro against OXA-48-like CRE strains than was imipenem-relebactam (90% susceptible versus 15% susceptible).

publication date

  • August 23, 2019

Research

keywords

  • Anti-Bacterial Agents
  • Azabicyclo Compounds
  • Carbapenem-Resistant Enterobacteriaceae
  • Imipenem

Identity

PubMed Central ID

  • PMC6709495

Scopus Document Identifier

  • 85071233009

Digital Object Identifier (DOI)

  • 10.1128/JCM.01924-13

PubMed ID

  • 31262761

Additional Document Info

volume

  • 63

issue

  • 9