Cure of hemophilia A by orthotopic liver transplantation. uri icon

Overview

abstract

  • A patient with hemophilia A and transfusion-associated end-stage chronic liver disease underwent orthotopic liver transplantation. He had no requirement for exogenous factor VIII replacement during the 27 mo he survived. Although his hemophilia was cured, he had antibodies to the human immunodeficiency virus; ultimately he died of complications arising from acquired immunodeficiency syndrome. Liver transplantation for cirrhotic hemophiliacs can free them of the need for antihemophilic-factor therapy; however, application of this approach may be limited by the high prevalence of human immunodeficiency virus infection in multitransfused hemophiliacs.

publication date

  • July 1, 1988

Research

keywords

  • Hemophilia A
  • Hepatitis C
  • Hepatitis, Viral, Human
  • Liver Transplantation

Identity

Scopus Document Identifier

  • 0023933735

Digital Object Identifier (DOI)

  • 10.1016/0016-5085(88)90310-1

PubMed ID

  • 3131178

Additional Document Info

volume

  • 95

issue

  • 1