Development of precision medicine approaches based on inter-individual variability of BCRP/ABCG2. Review uri icon

Overview

abstract

  • Precision medicine is a rapidly-developing modality of medicine in human healthcare. Based on each patient׳s unique characteristics, more accurate dosages and drug selection can be made to achieve better therapeutic efficacy and less adverse reactions in precision medicine. A patient׳s individual parameters that affect drug transporter action can be used to develop a precision medicine guidance, due to the fact that therapeutic efficacy and adverse reactions of drugs can both be affected by expression and function of drug transporters on the cell membrane surface. The purpose of this review is to summarize unique characteristics of human breast cancer resistant protein (BCRP) and the genetic variability in the BCRP encoded gene ABCG2 in the development of precision medicine. Inter-individual variability of BCRP/ABCG2 can impact choices and outcomes of drug treatment for several diseases, including cancer chemotherapy. Several factors have been implicated in expression and function of BCRP, including genetic, epigenetic, physiologic, pathologic, and environmental factors. Understanding the roles of these factors in controlling expression and function of BCRP is critical for the development of precision medicine based on BCRP-mediated drug transport.

publication date

  • January 15, 2019

Identity

PubMed Central ID

  • PMC6664102

Scopus Document Identifier

  • 85062447785

Digital Object Identifier (DOI)

  • 10.1016/j.apsb.2019.01.007

PubMed ID

  • 31384528

Additional Document Info

volume

  • 9

issue

  • 4