Bmi1 restricts the adipogenic differentiation of bone marrow stromal cells to maintain the integrity of the hematopoietic stem cell niche. Academic Article uri icon

Overview

abstract

  • The polycomb group protein Bmi1 maintains hematopoietic stem cell (HSC) functions. We previously reported that Bmi1-deficient mice exhibited progressive fatty changes in bone marrow (BM). A large portion of HSCs reside in the perivascular niche created partly by endothelial cells and leptin receptor+ (LepR+) BM stromal cells. To clarify how Bmi1 regulates the HSC niche, we specifically deleted Bmi1 in LepR+ cells in mice. The Bmi1 deletion promoted the adipogenic differentiation of LepR+ stromal cells and caused progressive fatty changes in the BM of limb bones with age, resulting in reductions in the numbers of HSCs and progenitors in BM and enhanced extramedullary hematopoiesis. This adipogenic change was also evident during BM regeneration after irradiation. Several adipogenic regulator genes appeared to be regulated by Bmi1. Our results indicate that Bmi1 keeps the adipogenic differentiation program repressed in BM stromal cells to maintain the integrity of the HSC niche.

publication date

  • August 11, 2019

Research

keywords

  • Adipogenesis
  • Hematopoietic Stem Cells
  • Polycomb Repressive Complex 1
  • Proto-Oncogene Proteins
  • Stem Cell Niche

Identity

Scopus Document Identifier

  • 85071510263

Digital Object Identifier (DOI)

  • 10.1016/j.exphem.2019.07.006

PubMed ID

  • 31408689

Additional Document Info

volume

  • 76