The risk of second primary tumors in head and neck cancer: A systematic review. Academic Article uri icon

Overview

abstract

  • BACKGROUND: Second primary tumors (SPTs) are a common cause of reduced life expectancy in patients treated for head and neck cancer (HNC). This phenomenon forms an area to be addressed during posttreatment follow-up. METHODS: We conducted a systematic review of literature following PRISMA guidelines, from 1979 to 2019, to investigate incidence of SPTs, synchronous, and metachronous, in HNC population. RESULTS: Our review includes data of 456 130 patients from 61 articles. With a minimum follow-up of 22 months, mean incidence of SPTs was 13.2% (95% CI: 11.56-14.84): 5.3% (95% CI: 4.24-6.36) for synchronous SPTs and 9.4% (95% CI: 7.9-10.9) for metachronous SPTs. The most frequent site for SPTs was head and neck area, followed by the lungs and esophagus. CONCLUSION: Although with wide variations between studies, the rate of SPTs in HNC patients is high. Given the impact in the prognosis, we must develop strategies for the early diagnosis of SPTs.

publication date

  • November 21, 2019

Research

keywords

  • Head and Neck Neoplasms
  • Neoplasms, Second Primary

Identity

Scopus Document Identifier

  • 85075475328

Digital Object Identifier (DOI)

  • 10.1002/hed.26016

PubMed ID

  • 31750595

Additional Document Info

volume

  • 42

issue

  • 3