The epichaperome is a mediator of toxic hippocampal stress and leads to protein connectivity-based dysfunction. Academic Article uri icon

Overview

abstract

  • Optimal functioning of neuronal networks is critical to the complex cognitive processes of memory and executive function that deteriorate in Alzheimer's disease (AD). Here we use cellular and animal models as well as human biospecimens to show that AD-related stressors mediate global disturbances in dynamic intra- and inter-neuronal networks through pathologic rewiring of the chaperome system into epichaperomes. These structures provide the backbone upon which proteome-wide connectivity, and in turn, protein networks become disturbed and ultimately dysfunctional. We introduce the term protein connectivity-based dysfunction (PCBD) to define this mechanism. Among most sensitive to PCBD are pathways with key roles in synaptic plasticity. We show at cellular and target organ levels that network connectivity and functional imbalances revert to normal levels upon epichaperome inhibition. In conclusion, we provide proof-of-principle to propose AD is a PCBDopathy, a disease of proteome-wide connectivity defects mediated by maladaptive epichaperomes.

authors

publication date

  • January 16, 2020

Research

keywords

  • Alzheimer Disease
  • Hippocampus
  • Neuronal Plasticity
  • Proteome

Identity

PubMed Central ID

  • PMC6965647

Scopus Document Identifier

  • 85077940839

Digital Object Identifier (DOI)

  • 10.1371/journal.pcbi.1005890

PubMed ID

  • 31949159

Additional Document Info

volume

  • 11

issue

  • 1