Murine and related chapparvoviruses are nephro-tropic and produce novel accessory proteins in infected kidneys. Academic Article uri icon

Overview

abstract

  • Mouse kidney parvovirus (MKPV) is a member of the provisional genus Chapparvovirus that causes renal disease in immune-compromised mice, with a disease course reminiscent of polyomavirus-associated nephropathy in immune-suppressed kidney transplant patients. Here we map four major MKPV transcripts, created by alternative splicing, to a common initiator region, and use mass spectrometry to identify "p10" and "p15" as novel chapparvovirus accessory proteins produced in MKPV-infected kidneys. p15 and the splicing-dependent putative accessory protein NS2 are conserved in all near-complete amniote chapparvovirus genomes currently available (from mammals, birds and a reptile). In contrast, p10 may be encoded only by viruses with >60% amino acid identity to MKPV. We show that MKPV is kidney-tropic and that the bat chapparvovirus DrPV-1 and a non-human primate chapparvovirus, CKPV, are also found in the kidneys of their hosts. We propose, therefore, that many mammal chapparvoviruses are likely to be nephrotropic.

publication date

  • January 23, 2020

Research

keywords

  • Kidney
  • Parvoviridae Infections
  • Parvovirinae
  • Rodent Diseases
  • Viral Proteins
  • Viral Tropism

Identity

PubMed Central ID

  • PMC6999912

Scopus Document Identifier

  • 85078899294

Digital Object Identifier (DOI)

  • 10.1371/journal.pone.0156132

PubMed ID

  • 31971979

Additional Document Info

volume

  • 16

issue

  • 1