Multifunctional Nanodelivery Platform for Maximizing Nucleic Acids Combination Therapy. Academic Article uri icon

Overview

abstract

  • The silencing of an oncogene with a small interfering RNA (siRNA) is a promising way for cancer therapy. Its efficacy can be further enhanced by integrating with other therapeutics; however, transporting siRNA and other active ingredients to the same location at the same time is challenging. Here, we report a novel multifunctional nanodelivery platform by sequentially layering several functional ingredients, such as siRNAs, microRNAs, peptides, and targeting ligands, onto a core through charge-charge interaction. The prepared nanovectors effectively and programmably delivered multiple active components to maximize therapeutic combination with minimal off-targeting effects.

publication date

  • January 1, 2020

Research

keywords

  • Drug Carriers
  • Nanoparticles
  • Neoplasms
  • RNA, Small Interfering

Identity

Scopus Document Identifier

  • 85078829276

Digital Object Identifier (DOI)

  • 10.1007/978-1-0716-0290-4_4

PubMed ID

  • 32006395

Additional Document Info

volume

  • 2115