Animal Models of Congenital Cytomegalovirus Transmission: Implications for Vaccine Development. Review uri icon

Overview

abstract

  • Although cytomegaloviruses (CMVs) are species-specific, the study of nonhuman CMVs in animal models can help to inform and direct research aimed at developing a human CMV (HCMV) vaccine. Because the driving force behind the development of HCMV vaccines is to prevent congenital infection, the animal model in question must be one in which vertical transmission of virus occurs to the fetus. Fortunately, two such animal models-the rhesus macaque CMV and guinea pig CMV-are characterized by congenital infection. Hence, each model can be evaluated in "proof-of-concept" studies of preconception vaccination aimed at blocking transplacental transmission. This review focuses on similarities and differences in the respective model systems, and it discusses key insights from each model germane to the study of HCMV vaccines.

publication date

  • March 5, 2020

Research

keywords

  • Cytomegalovirus
  • Cytomegalovirus Infections
  • Host-Pathogen Interactions
  • Infectious Disease Transmission, Vertical

Identity

PubMed Central ID

  • PMC7057791

Scopus Document Identifier

  • 85081944645

Digital Object Identifier (DOI)

  • 10.1128/JVI.01442-19

PubMed ID

  • 32134481

Additional Document Info

volume

  • 221

issue

  • Suppl 1