Association of interleukin-6 and tumor necrosis factor-α with mortality in hospitalized patients with cancer. Academic Article uri icon

Overview

abstract

  • BACKGROUND: Severe cutaneous adverse reactions (SCARs) are associated with high morbidity and mortality in patients with cancer. Early identification and treatment of SCARs may improve outcomes. OBJECTIVE: To identify biomarkers to predict outcomes in hospitalized patients with cancer who developed SCARs. METHODS: Retrospective review of 144 hospitalized patients with cancer with a morbilliform rash, recorded testing for serum cytokines (interleukin [IL]-6, IL-10, and tumor necrosis factor [TNF]-α) or elafin, and a dermatology consultation. Rashes were categorized as simple morbilliform rash without systemic involvement or complex morbilliform rash with systemic involvement. RESULTS: Fifty-four of 144 (37.5%) patients died during follow-up. Elevated levels of IL-6, IL-10, and TNF-α were associated with decreased survival. Overall survivals in patients with elevated levels of IL-6, IL-10, and TNF-α were 53.7%, 56.6%, 53.6%, respectively, compared with 85.7%, 82.5% and 83.6%, respectively, in those with lower levels. Patients with increased levels of both IL-6 and TNF-α had a nearly 6-fold increase in mortality (hazard ratio, 5.82) compared with patients with lower levels. LIMITATIONS: Retrospective design, limited sample size, and high-risk population. CONCLUSIONS: Hospitalized patients with cancer with rash and elevated IL-6 and TNF-α were nearly 6 times more likely to die over the course of follow-up. These biomarkers may serve as prognostic biomarkers and therapeutic targets for this high-risk population.

publication date

  • March 12, 2020

Research

keywords

  • Antineoplastic Agents
  • Biomarkers, Tumor
  • Drug Eruptions
  • Interleukin-6
  • Neoplasms
  • Tumor Necrosis Factor-alpha

Identity

PubMed Central ID

  • PMC7486231

Scopus Document Identifier

  • 85087717110

Digital Object Identifier (DOI)

  • 10.1016/j.jaad.2020.03.010

PubMed ID

  • 32171811

Additional Document Info

volume

  • 84

issue

  • 2