A novel metric for treatment durability in clinical trials of minimally invasive treatments for benign prostatic hyperplasia. Academic Article uri icon

Overview

abstract

  • Introduction: Clinical trial manuscripts commonly report results of individual endpoints. However, durability of a medical treatment may be difficult to determine when evaluating endpoint outcomes individually. We reviewed pivotal trial manuscripts of two minimally invasive benign prostatic hyperplasia (BPH) treatments and estimated the rate of treatment durability using a composite, symptom-centric metric.Methods: Data were derived from published pivotal trial reports of two minimally invasive BPH treatments - water vapor thermal therapy (WVTT) and prostatic urethral lift (PUL). We estimated the risk of medical or surgical retreatment using life-table methods, and the number of patients achieving the minimal clinically important difference (MCID) for the International Prostate Symptom Score (IPSS) using z-score methods. Treatment durability was defined as a MCID on the IPSS at the 4-year follow-up visit while free from medical or surgical retreatment.Results: Comparing WVTT to PUL, the rate of medical or surgical retreatment was 10.6% vs. 31.8%, the IPSS MCID was achieved in 82.2% vs. 79.5%, and treatment durability rates were 71.8% vs. 51.7%.Conclusions: Utilization of a composite treatment durability metric derived from endpoints commonly reported in the BPH literature may allow patients and their providers to make better informed treatment decisions.

publication date

  • March 19, 2020

Research

keywords

  • Clinical Trials as Topic
  • Minimally Invasive Surgical Procedures
  • Prostatic Hyperplasia

Identity

Scopus Document Identifier

  • 85082314409

Digital Object Identifier (DOI)

  • 10.1080/17434440.2020.1742699

PubMed ID

  • 32189535

Additional Document Info

volume

  • 17

issue

  • 4