Use of Botulinum Toxin A (BoNT-A) in Detrusor External Sphincter Dyssynergia (DESD): A Systematic Review and Meta-analysis. Review uri icon

Overview

abstract

  • We performed a systematic review to examine the efficacy and outcomes of Botulinum Toxin A (BoNT-A) as the primary intervention strategy for patients with detrusor external sphincter dyssynergia. Eleven studies were included in the analysis (n = 353; 16% female, 84% male). BoNT-A was effective in 60%-78% of patients for reducing postvoid residual, mean detrusor pressure, detrusor leak point pressure, and mean urethral pressure 1 month after injection. Most patients required reinjection after an average of 4-9 months. BoNT-A was not associated with any significant adverse events, and may improve quality of life, as well as urodynamic parameters for detrusor external sphincter dyssynergia.

publication date

  • March 19, 2020

Research

keywords

  • Anal Canal
  • Anus Diseases
  • Ataxia
  • Botulinum Toxins, Type A
  • Neuromuscular Agents

Identity

Scopus Document Identifier

  • 85083058365

Digital Object Identifier (DOI)

  • 10.1016/j.urology.2020.03.007

PubMed ID

  • 32197987

Additional Document Info

volume

  • 140