Number needed to biopsy ratio and diagnostic accuracy for melanoma detection. Academic Article uri icon

Overview

abstract

  • BACKGROUND: The number needed to biopsy (NNB) ratio for melanoma diagnosis is calculated by dividing the total number of biopsies by the number of biopsied melanomas. It is the inverse of positive predictive value (PPV), which is calculated by dividing the number of biopsied melanomas by the total number of biopsies. NNB is increasingly used as a metric to compare the diagnostic accuracy of health care practitioners. OBJECTIVE: To investigate the association of NNB with the standard statistical measures of sensitivity and specificity. METHODS: We extracted published diagnostic accuracy data from 5 cross-sectional skin cancer reader studies (median [min-max] readers/study was 29 [8-511]). Because NNB is a ratio, we converted it to PPV. RESULTS: Four studies showed no association and 1 showed a negative association between PPV and sensitivity. All 5 studies showed a positive association between PPV and specificity. LIMITATIONS: Reader study data. CONCLUSIONS: An individual health care practitioner with a lower NNB is likely to have a higher specificity than one with a higher NNB, assuming they practice under similar conditions; no conclusions can be made about their relative sensitivities. We advocate for additional research to define quality metrics for melanoma detection and caution when interpreting NNB.

publication date

  • April 29, 2020

Research

keywords

  • Early Detection of Cancer
  • Melanoma
  • Skin
  • Skin Neoplasms

Identity

PubMed Central ID

  • PMC7484328

Scopus Document Identifier

  • 85087341846

Digital Object Identifier (DOI)

  • 10.1016/j.jaad.2020.04.109

PubMed ID

  • 32360723

Additional Document Info

volume

  • 83

issue

  • 3