Why do young people get cancer? Review uri icon

Overview

abstract

  • Oncologists and cancer biologists are frequently confronted by the question of what causes cancer? This is particularly vexing for cancers affecting children and young adults who have had limited exposure to environmental mutagens and the effects of aging. Here, I focus on a general framework of the causes of early-onset cancer development in children and young adults by relating inherited and constitutional cancer predisposition, oncogenic pathogens, and developmental mutations. This framework has implications not only for mechanistic investigation of young cancers, but should also clarify improved strategies for their treatment, screening, and potential prevention.

publication date

  • May 11, 2020

Research

keywords

  • Genetic Predisposition to Disease
  • Mutation
  • Neoplasms
  • Oncogenic Viruses

Identity

PubMed Central ID

  • PMC7582786

Scopus Document Identifier

  • 85084510930

Digital Object Identifier (DOI)

  • 10.3389/fped.2020.00189

PubMed ID

  • 32391946

Additional Document Info

volume

  • 67

issue

  • 7