COVID-19-associated Diffuse Leukoencephalopathy and Microhemorrhages. Academic Article uri icon

Overview

abstract

  • Diffuse leukoencephalopathy and juxtacortical and/or callosal microhemorrhages were brain imaging features in critically ill patients with coronavirus disease 2019. Coronavirus disease 2019 (COVID-19) has been reported in association with a variety of brain imaging findings such as ischemic infarct, hemorrhage, and acute hemorrhagic necrotizing encephalopathy. Herein, the authors report brain imaging features in 11 critically ill patients with COVID-19 with persistently diminished mental status who underwent MRI between April 5 and April 25, 2020. These imaging features include (a) confluent T2 hyperintensity and mild restricted diffusion in bilateral supratentorial deep and subcortical white matter (in 10 of 11 patients) and (b) multiple punctate microhemorrhages in juxtacortical and callosal white matter (in seven of 11 patients). The authors also discuss potential pathogeneses.

publication date

  • May 21, 2020

Research

keywords

  • Brain
  • Cerebral Hemorrhage
  • Coronavirus Infections
  • Leukoencephalopathies
  • Pandemics
  • Pneumonia, Viral

Identity

PubMed Central ID

  • PMC7507998

Scopus Document Identifier

  • 85091469737

Digital Object Identifier (DOI)

  • 10.1007/s00701-020-04374-x

PubMed ID

  • 32437314

Additional Document Info

volume

  • 297

issue

  • 1