Quality of Life Concerns in Patients with Uveal Melanoma after Initial Diagnosis. Academic Article uri icon

Overview

abstract

  • BACKGROUND: Patients with uveal melanoma (UM) are known to have quality of life (QOL) issues after treatment, but QOL concerns after initial diagnosis are ill-defined. OBJECTIVES: We studied the QOL concerns of patients with UM after initial diagnosis to identify factors associated with QOL. METHOD: Between September 2011 and May 2016, UM planning to undergo radiotherapy completed the European Organization for Research and Treatment of Cancer (EORTC) core quality of life questionnaire (QLQ)-C30, as well as the Ophthalmic Oncology module, QLQ-OPT30. Demographic, ophthalmic, and tumor related characteristics were recorded. The primary outcome was the QOL score and fraction of patients reporting any or severe symptoms. A multiple stepwise regression model investigated the association of demographic, ophthalmic, and tumor characteristics with QOL. RESULTS: QOL concerns were assessed in 201 subjects. The majority (51/60) of QOL items had a high response rate (≥90%), and internal consistency on scales (median Cronbach α = 0.85) with the most common severe QOL concern being worry about disease recurrence (41%). The most common ophthalmic symptoms reported were vision impairment (81%) and ocular irritation (66%). Multivariable regression modeling demonstrated several significant associations. CONCLUSIONS: Severe worry about UM recurrence, ocular irritation, and vision impairment was reported by many patients. Clinicians should be aware of these concerns and implement management strategies.

publication date

  • September 27, 2019

Identity

PubMed Central ID

  • PMC7250345

Scopus Document Identifier

  • 85072779148

Digital Object Identifier (DOI)

  • 10.1159/000502549

PubMed ID

  • 32509764

Additional Document Info

volume

  • 6

issue

  • 3