Clonal hematopoiesis is associated with adverse outcomes in multiple myeloma patients undergoing transplant. Academic Article uri icon

Overview

abstract

  • Multiple myeloma (MM) is a plasma-cell neoplasm that is treated with high-dose chemotherapy, autologous stem cell transplant (ASCT) and long-term immunomodulatory drug (IMiD) maintenance. The presence of somatic mutations in the peripheral blood is termed clonal hematopoiesis of indeterminate potential (CHIP) and is associated with adverse outcomes. Targeted sequencing of the stem cell product from 629 MM patients treated by ASCT at the Dana-Farber Cancer Institute (2003-2011) detects CHIP in 136/629 patients (21.6%). The most commonly mutated genes are DNMT3A, TET2, TP53, ASXL1 and PPM1D. Twenty-one from fifty-six patients (3.3%) receiving first-line IMiD maintenance develop a therapy-related myeloid neoplasm (TMN). However, regardless of CHIP status, the use of IMiD maintenance associates with improved PFS and OS. In those not receiving IMiD maintenance, CHIP is associated with decreased overall survival (OS) (HR:1.34, p = 0.02) and progression free survival (PFS) (HR:1.45, p < 0.001) due to an increase in MM progression.

authors

publication date

  • June 12, 2020

Research

keywords

  • Antineoplastic Combined Chemotherapy Protocols
  • Hematopoiesis
  • Hematopoietic Stem Cell Transplantation
  • Multiple Myeloma
  • Mutation

Identity

PubMed Central ID

  • PMC7293239

Scopus Document Identifier

  • 85086366630

Digital Object Identifier (DOI)

  • 10.1038/s41467-020-16805-5

PubMed ID

  • 32533060

Additional Document Info

volume

  • 11

issue

  • 1