Protective Effects of SIRT6 Overexpression against DSS-Induced Colitis in Mice. Academic Article uri icon

Overview

abstract

  • Sirtuin 6 (SIRT6), as a NAD + -dependent deacetylase, plays an indispensable role in the regulation of health and physiology. Loss of SIRT6 causes spontaneous colitis in mice and makes intestinal epithelial cells prone to stress. However, whether SIRT6 overexpression increases resistance to colitis remains unknown. Here, in vivo results demonstrated that SIRT6 overexpression attenuates DSS-induced colitis in terms of clinical manifestations, histopathological damage, loss of tight junction function and imbalanced intestinal microenvironment. Additionally, we also found that the activation of NF-κB and c-Jun induced by DSS is diminished by SIRT6 overexpression. Furthermore, SIRT6 may regulate TAK1 to inhibit NF-κB and c-Jun signaling. Thus, our findings highlight the protective effect of SIRT6 on colon, further supporting the perspective that SIRT6 may be a therapeutic target for intestine injury under stress.

publication date

  • June 22, 2020

Research

keywords

  • Colitis
  • Sirtuins

Identity

PubMed Central ID

  • PMC7348883

Scopus Document Identifier

  • 85087100273

Digital Object Identifier (DOI)

  • 10.1186/s12974-019-1432-5

PubMed ID

  • 32580272

Additional Document Info

volume

  • 9

issue

  • 6