Transcription factor 21 expression in injured podocytes of glomerular diseases. Academic Article uri icon

Overview

abstract

  • Transcription factor 21 (TCF21) is one of the essential transcription factors in kidney development. To elucidate its influence on glomerular disease, we have investigated TCF21 expression in human and rat kidney tissue, and its urinary concentration. Immunohistological analysis suggested the highest TCF21 expression in nephrotic syndrome along with the urinary protein level. Urinary TCF21 concentration in human showed a positive correlation with its podocyte expression level. In nephrotic rat models, TCF21 expression in podocytes increased along with the severity of nephrotic syndrome. Next, in vitro experiments using Tcf21-expressing murine podocyte cell line, we could observe some Tcf21-dependent effects, related with actin cytoskeleton dysregulation and apoptosis. Our study illustrated TCF21 expression changes in vivo and its in vitro-functional significance injured podocytes.

publication date

  • July 13, 2020

Research

keywords

  • Basic Helix-Loop-Helix Transcription Factors
  • Kidney Diseases
  • Kidney Glomerulus

Identity

PubMed Central ID

  • PMC7359327

Scopus Document Identifier

  • 85087895607

Digital Object Identifier (DOI)

  • 10.1038/ncomms4296

PubMed ID

  • 32661376

Additional Document Info

volume

  • 10

issue

  • 1