ITLN1 modulates invasive potential and metabolic reprogramming of ovarian cancer cells in omental microenvironment. Academic Article uri icon

Overview

abstract

  • Advanced ovarian cancer usually spreads to the omentum. However, the omental cell-derived molecular determinants modulating its progression have not been thoroughly characterized. Here, we show that circulating ITLN1 has prognostic significance in patients with advanced ovarian cancer. Further studies demonstrate that ITLN1 suppresses lactotransferrin's effect on ovarian cancer cell invasion potential and proliferation by decreasing MMP1 expression and inducing a metabolic shift in metastatic ovarian cancer cells. Additionally, ovarian cancer-bearing mice treated with ITLN1 demonstrate marked decrease in tumor growth rates. These data suggest that downregulation of mesothelial cell-derived ITLN1 in the omental tumor microenvironment facilitates ovarian cancer progression.

publication date

  • July 15, 2020

Research

keywords

  • Carcinoma, Ovarian Epithelial
  • Cytokines
  • Lectins
  • Omentum
  • Ovarian Neoplasms
  • Peritoneal Neoplasms

Identity

PubMed Central ID

  • PMC7363861

Scopus Document Identifier

  • 85088047650

Digital Object Identifier (DOI)

  • 10.2307/2531595

PubMed ID

  • 32669559

Additional Document Info

volume

  • 11

issue

  • 1