Mitochondrial control of innate immune signaling by irradiated cancer cells. Editorial Article uri icon

Overview

abstract

  • Type I interferon (IFN) release by irradiated cancer cells is paramount for radiation therapy to elicit anticancer immunity. Our findings demonstrate that mitochondrial outer membrane permeabilization (MOMP) triggered by RT enables exposure of mitochondrial DNA to the cytosol, hence setting off CGAS-driven type I IFN synthesis. These data point to the existence of a therapeutically actionable mitochondrial checkpoint that restricts innate immune signaling in irradiated cancer cells.

publication date

  • July 22, 2020

Research

keywords

  • Interferon Type I
  • Neoplasms

Identity

PubMed Central ID

  • PMC7458622

Scopus Document Identifier

  • 85088435517

Digital Object Identifier (DOI)

  • 10.1158/2159-8290.CD-18-1151

PubMed ID

  • 32923160

Additional Document Info

volume

  • 9

issue

  • 1