Artificial intelligence in COVID-19 drug repurposing. Review uri icon

Overview

abstract

  • Drug repurposing or repositioning is a technique whereby existing drugs are used to treat emerging and challenging diseases, including COVID-19. Drug repurposing has become a promising approach because of the opportunity for reduced development timelines and overall costs. In the big data era, artificial intelligence (AI) and network medicine offer cutting-edge application of information science to defining disease, medicine, therapeutics, and identifying targets with the least error. In this Review, we introduce guidelines on how to use AI for accelerating drug repurposing or repositioning, for which AI approaches are not just formidable but are also necessary. We discuss how to use AI models in precision medicine, and as an example, how AI models can accelerate COVID-19 drug repurposing. Rapidly developing, powerful, and innovative AI and network medicine technologies can expedite therapeutic development. This Review provides a strong rationale for using AI-based assistive tools for drug repurposing medications for human disease, including during the COVID-19 pandemic.

publication date

  • September 18, 2020

Research

keywords

  • Artificial Intelligence
  • COVID-19 Drug Treatment
  • Drug Repositioning

Identity

PubMed Central ID

  • PMC7500917

Scopus Document Identifier

  • 85087778699

Digital Object Identifier (DOI)

  • 10.1002/med.21709

PubMed ID

  • 32984792

Additional Document Info

volume

  • 2

issue

  • 12