The contribution of uncoupling protein 2 to mitochondrial Ca2+ homeostasis in health and disease - A short revisit. Review uri icon

Overview

abstract

  • Considering the versatile functions attributed to uncoupling protein 2 (UCP2) in health and disease, a profound understanding of the protein's molecular actions under physiological and pathophysiological conditions is indispensable. This review aims to revisit and shed light on the fundamental molecular functions of UCP2 in mitochondria, with particular emphasis on its intricate role in regulating mitochondrial calcium (Ca2+) uptake. UCP2's modulating effect on various vital processes in mitochondria makes it a crucial regulator of mitochondrial homeostasis in health and disease.

authors

  • Koshenov, Zhanat
  • Oflaz, Furkan E
  • Hirtl, Martin
  • Bachkoenig, Olaf A
  • Rost, Rene
  • Osibow, Karin
  • Gottschalk, Benjamin
  • Madreiter-Sokolowski, Corina T
  • Waldeck-Weiermair, Markus
  • Malli, Roland
  • Graier, Wolfgang F

publication date

  • October 15, 2020

Research

keywords

  • Calcium
  • Mitochondria
  • Mitochondrial Diseases
  • Uncoupling Protein 2

Identity

Scopus Document Identifier

  • 85094613531

Digital Object Identifier (DOI)

  • 10.1016/j.mito.2020.10.003

PubMed ID

  • 33069910

Additional Document Info

volume

  • 55