The S-phase-induced lncRNA SUNO1 promotes cell proliferation by controlling YAP1/Hippo signaling pathway. Academic Article uri icon

Overview

abstract

  • Cell cycle is a cellular process that is subject to stringent control. In contrast to the wealth of knowledge of proteins controlling the cell cycle, very little is known about the molecular role of lncRNAs (long noncoding RNAs) in cell-cycle progression. By performing genome-wide transcriptome analyses in cell-cycle-synchronized cells, we observed cell-cycle phase-specific induction of >2000 lncRNAs. Further, we demonstrate that an S-phase-upregulated lncRNA, SUNO1, facilitates cell-cycle progression by promoting YAP1-mediated gene expression. SUNO1 facilitates the cell-cycle-specific transcription of WTIP, a positive regulator of YAP1, by promoting the co-activator, DDX5-mediated stabilization of RNA polymerase II on chromatin. Finally, elevated SUNO1 levels are associated with poor cancer prognosis and tumorigenicity, implying its pro-survival role. Thus, we demonstrate the role of a S-phase up-regulated lncRNA in cell-cycle progression via modulating the expression of genes controlling cell proliferation.

publication date

  • October 27, 2020

Research

keywords

  • Cell Proliferation
  • Co-Repressor Proteins
  • Cytoskeletal Proteins
  • DEAD-box RNA Helicases
  • Gene Expression Regulation
  • RNA, Long Noncoding
  • Signal Transduction

Identity

PubMed Central ID

  • PMC7591261

Scopus Document Identifier

  • 85094850040

Digital Object Identifier (DOI)

  • 10.1101/gad.1664408

PubMed ID

  • 33108271

Additional Document Info

volume

  • 9